- Turkish Journal of Chemistry
- Vol: 22 Issue: 4
- Voltammetric Determination of Thioridazine Hydrochloride
Voltammetric Determination of Thioridazine Hydrochloride
Authors : Inci Biryol, Saadet Dermiş
Pages : 325-334
View : 10 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :This study describes the optimal conditions for the determination of Thioridazine HCl (Tz-HCl) in 0.2 M sulphuric acid by voltammetry using ruthenium (Ru), platinum (Pt) and glassy carbon (GC) electrodes. A new and sensitive method is described for electrochemical determination of Tz-HCl in the concentration range 5.10-5 - 10-3 M (20.35-407 mgml-1); 6.10-4 - 10-2 M (244.2 - 4070 mgml-1); 10-4 - 10-3 M (40,7 - 407 mgml-1), with Ru, Pt and glassy carbon electrodes, respectively. The method was applied successfully to the determination of Tz-HCl in pure form or incorporated in their representative pharmaceutical preparations. The precision of the assay was comparable with that of the official assays.Keywords : Thioridazine hydrochloride, voltammetry, ruthenium, platinum, glassy carbon electrodes.