- Turkish Journal of Chemistry
- Vol: 23 Issue: 3
- Conformational Analysis of Linear Peptide (Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7NH2 )
Conformational Analysis of Linear Peptide (Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7NH2 )
Authors : L. Demir, A. Karabulut, G. Budak, Y. Şahin
Pages : 257-262
View : 10 | Download : 7
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Conformational energy-minimization of the Sea Anemone and Sea Pansy neuropeptide Pol-RFamide (Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7-NH2) was carried out by molecular mechanics (MM). The linkage bonds were characterized by the torsion angles q, y and w and the side groups were characterized by the torsion angles c1, c2, c3\ldots The energy-map for each monopeptide of the Pol-RFamide I was drawn in the range of -180° to 180° with increments of 20°. Conformation facilities for monopeptides were determined from these maps. These results were used in the analysis of the dipeptide (Glu1-Leu2). Then, the (Glu1-Leu2-Leu3) tripeptide was examined using the calculated results for the dipeptide. Conformational analysis of the (Glu1-Leu2-Leu3-Gly4) tetrapeptide was performed using the low-energy values for the tripeptide. The space structure of the (Glu1-Leu2-Leu3-Gly4-Gly5-Arg6-Phe7-NH2) neuropeptide was found as a result of minimization of energies by rotating the tetrapeptide (Glu1-Leu2-Leu3-Gly4) and the dipeptide (Arg6-Phe7-NH2) about the monopeptide (Gly5).Keywords : Turk. J. Chem., 23, (1999), 257-262. Full text: pdf Other articles published in the same issue: Turk. J. Chem., vol.23, iss.3.