- Turkish Journal of Chemistry
- Vol: 24 Issue: 4
- Ion-Selective Membrane Electrode for the Determination of a Novel Phenylpiperazine Antidepressant, N...
Ion-Selective Membrane Electrode for the Determination of a Novel Phenylpiperazine Antidepressant, Nefazodone
Authors : Arzum Erdem, Dilşat Özkan, Kağan Kerman, Burcu Meriç
Pages : 353-360
View : 9 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :The construction and performance characteristics of ion-selective membrane electrodes for a newly found phenylpiperazine antidepressant, Nefazodone (NFN), based on its ion-pair complexes with phosphotungstate (PT), tetraphenylborate (TPB), tungstosilicate (TS) and reineckate (RN) in a poly(vinyl chloride) (PVC) matrix are described. The best ion-selective electrode for determination of NFN contains NFN-PT as the active material. This electrode exhibits a Nernstian response (62.6 ± 0.4 mV per decade) in the range 1.5 x 10-5 to 1.0 x 10-2 M NFN.HCl in solutions. The selectivity of this electrode to NFN in the presence of a number of sugar molecules, cations and drugs is reported. The potentiometric standard addition method and the argentometric titration method are used to determine the NFN amount in pure solution.Keywords : Turk. J. Chem., 24, (2000), 353-360. Full text: pdf Other articles published in the same issue: Turk. J. Chem., vol.24, iss.4.