- Turkish Journal of Chemistry
- Vol: 26 Issue: 6
- Spectrophotometric Determination of Mexiletine Hydrochloride in Capsules Using Bromothymol Blue
Spectrophotometric Determination of Mexiletine Hydrochloride in Capsules Using Bromothymol Blue
Authors : Zeynep Aydoğmuş, S. Müge Çetin, Sedat Tosunoğlu
Pages : 839-842
View : 8 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A new spectrophotometric method based on the formation of an ion-pair using bromothymol blue as ion-pair complexing reagent was developed for the determination of mexiletine hydrochloride in capsules. The ion-pair formed was highly coloured and easily extracted with dichloromethane. The calibration curve was linear over the concentration range 1.08--10.8 m g.ml-1 at lmax = 408 nm (r = 0.9999). The results obtained from the developed method were compared statistically with those obtained by the British Pharmacopeia method.Keywords : Spectrophotometry, Mexiletine hydrochloride, Bromothymol blue, Ion-pair.