- Turkish Journal of Chemistry
- Vol: 27 Issue: 2
- Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge
Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge
Authors : Deniz Taşdemir
Pages : 273-279
View : 9 | Download : 8
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to b -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR, [a]D, EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.Keywords : Marine sponge, Didiscus, (+)-curcuphenol, (+)-curcudiol, b -sitosterol, phenethylamine, HCT-116