- Turkish Journal of Chemistry
- Vol: 27 Issue: 4
- Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and...
Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and Anti-Inflammatory Properties
Authors : H. Ozan Gülcan, Serdar Ünlü, Erden Banoğlu, M. Fethi Şahin
Pages : 467-476
View : 7 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, 1H-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.Keywords : 2-Oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2.