- Turkish Journal of Chemistry
- Vol: 27 Issue: 5
- DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases
DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases
Authors : Murat Kizil
Pages : 539-544
View : 13 | Download : 7
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copper(II) chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.Keywords : Aryl radicals, diazonium salts, DNA cleavage