- Turkish Journal of Chemistry
- Vol: 28 Issue: 3
- Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the...
Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide
Authors : Bashir Ahmad, Shumaila Bashir, Shams-un Nisa, M. B. Huglin
Pages : 279-286
View : 11 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r1 = 0.045 and r2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.Keywords : N-vinyl-2-pyrrolidone, 2-hydroxyethyl methacrylate, Hydrogels, Drug release