- Turkish Journal of Chemistry
- Vol: 28 Issue: 4
- Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,...
Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,3,4-thiadiazole
Authors : Tijen Önkol, Bilge Çakir, M. Fethi Şahin
Pages : 461-468
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Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and 1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.Keywords : 2-Oxobenzothiazoline, 1, 3, 4-thiadiazole, antinociceptive activity