- Turkish Journal of Chemistry
- Vol: 28 Issue: 4
- Synthesis and Microbiological Activity of Some Substituted N-(2-hydroxy-4-nitrophenyl)benzamides and...
Synthesis and Microbiological Activity of Some Substituted N-(2-hydroxy-4-nitrophenyl)benzamides and Phenylacetamides as Possible Metabolites of Antimicrobial Active Benzoxazoles
Authors : Ilkay Yildiz Ören, Esin Aki-şener, Cengiz Ertaş
Pages : 441-450
View : 12 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Some new antimicrobial active N-(2-hydroxy-4-nitrophenyl)- p-substituted benzamide and phenylacetamide analogues (I-II) were prepared by 2-step procedures from the corresponding carboxylic acids as possible metabolites of benzoxazoles. Their antimicrobial activities were tested against 3 Gram-positive and 2 Gram-negative bacteria with the fungus Candida albicans and were also compared with several control drugs. The compounds Ia, Id, IIa, and IIe were active at a MIC value of 12.5 m g/mL against the Gram-positive microorganism Bacillus subtilis. Most of the compounds exhibited antifungal activity at a MIC value of 12.5 m g/mL against C. albicans. On the other hand, the antimicrobial activity of some amide derivatives (Ia, Id, IIa-c) was also compared with their cyclic analogues, benzoxazole derivatives (III-IV). The compound Id significantly possessed 2 or 3 dilutions better antimicrobial activity than its heterocyclic derivative, 2-(p-t-butylphenyl)-5-nitrobenzoxazole, IIId, against Staphylococcus aureus, Streptococcus faecalis, Klebsiella pneumonia, and Escherichia coli.Keywords : Antimicrobial activity, benzamide, benzoxazole, phenylacetamide