- Turkish Journal of Chemistry
- Vol: 28 Issue: 4
- An Efficient Synthesis of Substituted 4-Aryl-3-Cyano-2-Amino Thiophenes by a Stepwise Gewald Reactio...
An Efficient Synthesis of Substituted 4-Aryl-3-Cyano-2-Amino Thiophenes by a Stepwise Gewald Reaction
Authors : Ferhan Tümer, Duygu Ekinci, Kani Zilbeyaz And Ümit Demir
Pages : 395-404
View : 13 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :The title compounds were efficiently synthesised starting from aryl methyl ketones in 3 steps. Knoevenagel condensation of aryl methyl ketones with malononitrile gave the corresponding crotonitriles (5a-f). Methyl groups of the crotonitriles (5a-f) were then efficiently brominated by refluxing and lightening the reaction media to give bromocrotonitriles (6a-f). The bromocrotonitriles (6a-f) were finally cyclised by treatment with NaSH to give the title compounds.Keywords : Aminothiophenes, bromocrotonitriles, substituted aminothiophenes