- Turkish Journal of Chemistry
- Vol: 29 Issue: 3
- Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivativ...
Synthesis of Some New Dihalophenyl- and Dihalobenzylisocoumarins and Their (dl)-3,4-Dihydroderivatives
Authors : Zahid Shafiq, Muhammad Arfan, Nasim Hasan Rama, Shahid Hameed, Ghulam Abbas, Muhammad Tahir Hussain
Pages : 321-325
View : 15 | Download : 7
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :3-Dihalophenyl- and dihalobenzylisocoumarins (3a-c) were synthesized by condensation of homophthalic acid (1) with dihalobenzoyl- and dihalophenylacetyl chlorides (2a-c), respectively. The alkaline hydrolysis of these isocoumarins (2a-c) afforded keto-acids (4a-c). (dl)-3-(Dihalophenyl)- and (dl)-3-(dihalobenzyl)- 3,4-dihydroisocoumarins (6a-c) were obtained by reduction of keto-acids (4a-c) to racemic hydroxy-acids (5a-c) followed by cyclodehydration using acetic anhydride.Keywords : Dihaloisocoumarins, Dihydrodihaloisocoumarins, synthesis.