- Turkish Journal of Chemistry
- Vol: 29 Issue: 3
- Synthesis, Characterization and Primary Antimicrobial Activity Evaluation of 3-Phenyl-6-methyl-4(3H)...
Synthesis, Characterization and Primary Antimicrobial Activity Evaluation of 3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic Acid Arylidenehydrazides
Authors : Aysel Gürsoy, Banu Ünal
Pages : 233-246
View : 11 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :3-Phenyl-6-methyl-4(3H)-quinazolinone-2-yl-mercaptoacetic acid hydrazide (3) was reacted with substituted aldehydes in absolute ethanol to obtain a new series, 3-phenyl-6-methyl-4(3H)-quinazolinone- 2-yl-mercaptoacetic acid arylidenehydrazides (4a-q). The structures of 4a-q were elucidated by elemental analyses and from spectrometric (UV, IR, 1H-NMR, 13C-NMR and EIMS) data. Then 4a-q were evaluated for antibacterial, antifungal and antitubercular activities. No significant activity was observed against the selected microorganisms.Keywords : 4(3H)-Quinazolinone, arylidenehydrazide, synthesis, antimicrobial activity.