- Turkish Journal of Chemistry
- Vol: 29 Issue: 4
- O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity
O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity
Authors : Dilek Ercil, Maeki Kaloga, Oliver A. Radtke, M. Koray Sakar, Albrecht F. Kiderlen, Herbert Kolodziej
Pages : 437-443
View : 10 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :From the aerial parts of Geranium pyrenaicum Burm., a new flavonol glycoside, kaempferol 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (7), along with 6 known related glycosides [kaempferol 3-O-b-D-glucopyranoside (1), quercetin 3-O-b-D-glucopyranoside (2), quercetin 3-O-b-D-galactopyranoside (3), kaempferol 3-O-(2''-O-galloyl)-b-D-glucopyranoside (4), quercetin 3-O-(2''-O-galloyl)-b-D-glucopyranoside (5) and quercetin 3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (6)] and the ellagitannins corilagin (8) and tellimagrandin I (9) were isolated. Their structures were established from spectroscopic studies (UV, FAB-MS, 1H and 13C-NMR, 1H-1H COSY, HETCOR, HMBC). Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species (L. major, L. donovani and L. amazonensis), indicating appreciable in vitro activities (IC50 4-27 nM) when compared with Pentostam (IC50 10-11 nM).Keywords : Geranium pyrenaicum, Geraniaceae, Flavonoids, Ellagitannins, Antileishmanial activity