- Turkish Journal of Chemistry
- Vol: 29 Issue: 6
- Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole ...
Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands
Authors : Öztekin Algül, Berrin Özçelik
Pages : 607-615
View : 11 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and 1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.Keywords : Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test