- Turkish Journal of Chemistry
- Vol: 31 Issue: 2
- Chemoenzymatic Synthesis of 2-Bromo-6-Hydroxy-3-Methoxy-2-Cyclohexen-1-one
Chemoenzymatic Synthesis of 2-Bromo-6-Hydroxy-3-Methoxy-2-Cyclohexen-1-one
Authors : Emine Özgül Karaaslan, Yasemin Toka
Pages : 149-153
View : 14 | Download : 8
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A chemoenzymatic synthesis of 2-bromo-6-hydroxy-3-methoxy-2- cyclohexen-1-one starting from cyclohexane-1,3-dione is reported. Manganese(III) acetate-mediated acetoxylation followed by the enzyme-mediated hydrolysis of a'-acetoxy enone affords hydroxy-enone 5 and acetoxy enone 4 with high enantiomeric excesses in good yields.Keywords : Chemoenzymatic synthesis, cyclic polyoxo cyclohexenones, manganese(III) acetate, acetoxylation