- Turkish Journal of Chemistry
- Vol: 31 Issue: 3
- Synthesis, Spectroscopic Investigation, Crystal Structure, and Biological Screening, Including Antit...
Synthesis, Spectroscopic Investigation, Crystal Structure, and Biological Screening, Including Antitumor Activity, of Organotin(IV) Derivatives of Piperonylic Acid
Authors : Muhammad Hanif, Mukhtiar Hussain, Saqib Ali, Moazzam H. Bhatti
Pages : 349-361
View : 12 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :We prepared 8 new organotin compounds with the general formulae [R3SnL], where R = Me (1), Bu (2), Ph (3), and Cy (4) and [R2SnL2], where R = Me (5), Et (6), Bu (7), Oct (8), and L = piperonylic acid, and characterized them by elemental analyses, IR spectra, and multinuclear NMR (1H, 13C, and 119Sn). The structure of 5 was confirmed by single crystal X-ray crystallography. The geometry around the tin atom was compared in both solution and solid state. Crystals of 5 are monoclinic with the space group P21/c. The tin geometry is skew trapezoidal bipyramidal, with 2 longer and 2 shorter Sn-O bonds; thus, the ligand chelates the Sn center in an asymmetric way. The synthesized compounds were also screened for antibacterial, antifungal, brine-shrimp lethality, and potato disc antitumor activity.Keywords : Organotin(IV) compounds, FT-IR, multinuclear NMR, X-ray structures, antibacterial, antifungal, brine-shrimp lethality, antitumor activities