- Turkish Journal of Chemistry
- Vol: 31 Issue: 3
- An Electrochemical DNA Biosensor for the Detection of DNA Damage Caused by Radioactive Iodine and Te...
An Electrochemical DNA Biosensor for the Detection of DNA Damage Caused by Radioactive Iodine and Technetium
Authors : Pınar Kara, Kağan Dağdeviren, Mehmet Özsöz
Pages : 243-249
View : 14 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A DNA damage process by radioactive iodine (I-131) and technetium (Tc-99m) is described. The procedure relies on a label-free electrochemical DNA biosensor. Fish sperm double stranded DNA was immobilized onto a carbon paste electrode (CPE) by electro deposition and the changes to the guanine oxidation signal were observed upon exposure to radioactive I-131 and Tc-99m by differential pulse voltammetry (DPV). The changes to the signal of guanine after exposure to therapeutic doses of Tc-99m and I-131 showed conformational changes in DNA molecules.Keywords : Electrochemistry, DNA damage, Tc-99m, iodine-131