- Turkish Journal of Chemistry
- Vol: 32 Issue: 3
- Characterization and Antimicrobial Activity of Organotin(IV) Complexes of 2-[(2 ,6 -diethylphenyla...
Characterization and Antimicrobial Activity of Organotin(IV) Complexes of 2-[(2 ,6 -diethylphenylamido)]benzoates and 3-[(2 ,6 -diethylphenylamido)]propanoates
Authors : Saira Shahzadi, Khadija Shahid, Saqib Ali, Mohammad Bakhtiar
Pages : 333-353
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Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :New organotin(IV) complexes with 2-[(2',6'-diethylphenylamido)] benzoic acid (HL1) and 3-[(2',6' -diethylphenylamido)]propanoic acid (HL2) were synthesized by the reaction of di- and triorganotin salts in the presence of triethylamine as base or dioctyltin oxide using a Dean and Stark trap for the removal of azeotropic water. All complexes were characterized by elemental analysis, IR, NMR, and mass spectral studies, and proof that tin-ligand coordination involves only the carboxylate group and complexes show hexa-coordinated geometry in solid state. Multinuclear NMR data show that triorganotin complexes exhibit 4-coordinated geometry while diorganotin complexes show a coordination number greater than 4, probably 5 or 6 in solution state. These complexes were screened to check their antimicrobial activity in vitro. The complexes of 2-[(2' ,6' -diethylphenylamido)benzoic acid (HL1) were also checked for their insecticidal and anti-leishmanial activity. All the complexes show significant activity with few exceptions.Keywords : Organotin(IV) carboxylates, spectroscopy, anti-leishmanial, insecticidal antibectrial, antifungal, cytotoxicity