A Mild Method for the Cleavage of Ketals Using IBX
Authors : Abdul Rauf Raza
Pages : 209-214
View : 11 | Download : 7
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.Keywords : Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.