- Turkish Journal of Chemistry
- Vol: 33 Issue: 3
- Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-...
Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes
Authors : Aydın Tavman, Serkan Ikiz, A. Funda Bağcigil, N. Yakut Özgür, Seyyal Ak
Pages : 321-331
View : 11 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3, Cu(NO3)2, AgNO3, and Zn(NO3)2 were synthesized and characterized. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and 1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum inhibitory concentration (MIC) dilution method, against 9 bacteria, and the results were compared with penicillin-G and oxytetracycline. It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2 are effective on S. epidermidis, S. aureus, and B. subtilis (gram+) organisms compared with the other compounds. All compounds except HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S. aureus.Keywords : 4-Methoxy-benzimidazolylphenol, metal complexes, antibacterial activity.