- Turkish Journal of Chemistry
- Vol: 33 Issue: 5
- Synthesis of methyl (E)-2',4''-thiazachalcones and their N-alkyl derivatives, photochemistry with th...
Synthesis of methyl (E)-2',4''-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities
Authors : Asu Usta, Ahmet Yaşar, Nuran Yayli
Pages : 621-632
Doi:10.3906/sag-1206-58
View : 12 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A series of 9 new (E)-thiazachalcones (1-3), and their N-alkyl substituted derivatives (4-6), and stereoselective dimerization products (7-9) were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds (1-6) without dimerization products (7-9) showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds (1-3) were calculated theoretically. Experimental and theoretical calculation showed that d-truxinic type dimer is the most stable isomer.Keywords : Thiazachalcones, N-decyl-4-thiazaclaconium bromide, photodimerization, antimicrobial activity.