- Turkish Journal of Chemistry
- Vol: 34 Issue: 2
- Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial acti...
Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity
Authors : Synthesis Of Some New Biheterocyclic Tri And
Pages : 165-180
Doi:10.3906/sag-1208-2
View : 12 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :2-{3-(4-Substitutedbenzyl)-4-[2-(1H-indol-3-yl)ethyl]-5-oxo-4,5- dihydro-1H-1,2,4-triazol-1-yl}-N'-(aryl-methylene)acetohydrazides (5a-g), 4-amino-2-{-(4-substitutedbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol- 1-yl}-N'-(arylmethylene)acetohydrazides (6a,b), and 4-[2-(1H-indol- 3-yl)ethyl]-5-(4-substitutedbenzyl)-2-{5-(phenylamino)-1,3,4-thiadiazol- 2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-ones (8a,b) were synthesized starting from 4-alkyl-5-(4-substitutedbenzyl)-2,4-dihydro- 3H-1,2,4-triazol-3-ones (2a-c) by several steps and their structures were well characterized by elemental analyses, IR, 1H-NMR, 13C-NMR, and mass spectral studies. They were also screened for their microbial activities. The obtained antimicrobial activity results revealed that 12 among the 24 compounds tested displayed variable growth inhibition effects on the tested gram-positive and gram-negative bacterial strains. None of the compounds showed antifungal activity against yeast-like fungi.Keywords : 1, 2, 4-Triazole, 1H-indole, 1, 3, 4-thiadiazole, Schiff base, antimicrobial activity.