- Turkish Journal of Chemistry
- Vol: 34 Issue: 3
- Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-tri...
Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas
Authors : Aamer Saeed, Rasheed Ahmad Khera, Naeem Abbas, Muhammad Latif
Pages : 335-346
Doi:10.3906/sag-1206-11
View : 8 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Synthesis of some novel 1-(3,4,5-trimethoxy)benzoyl-3- arylthiourea derivatives (1a-o) was accomplished in 2 steps. The synthetic route involves the reaction of 1-(3,4,5-trimethoxy)benzoyl chloride with potassium thiocyanate in 1:1 molar ratio in acetone to afford the corresponding isothiocyante followed by treatment with suitably substituted anilines. The structures of the products were established by elemental analyses, IR, 1H- and 13C-NMR, and mass spectroscopy and for 1b and 1m from single crystal X-ray diffraction data. All of the synthesized compounds (1a-o) were screened for antibacterial activity against gram positive and gram negative bacterial strains and were found to exhibit low activity towards the tested microorganisms, compared to chloramphenicol, the standard drug.Keywords : 1-(3, 4, 5-trimethoxy)benzoyl-3-arylthioureas, antibacterial, crystal structure.