- Turkish Journal of Chemistry
- Vol: 34 Issue: 6
- Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase ...
Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products
Authors : Muhammad Iqbal Choudhary
Pages : 945-952
Doi:10.3906/sag-1206-72
View : 12 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Biotransformation of danazol (17b-hydroxy-17a-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium solani yielded 17b-hydroxy-2-(hydroxymethyl)-17a -pregn-4-en-20-yn-3-one (2) and 17b -hydroxy-2-(hydroxymethyl)-17a-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol (1) and its transformed products 2 and 3 are also studied.Keywords : Biotransformation, danazol, Fusarium solani, Gibberella fujikuorii, prolyl endopeptidase (PEP) inhibition assay