- Turkish Journal of Chemistry
- Vol: 35 Issue: 1
- Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one d...
Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives
Authors : Oya Ünsal Tan, Keriman Özadali, Özgür Yeşilyurt
Pages : 121-130
Doi:10.3906/vet-1204-32
View : 10 | Download : 2
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).Keywords : Isoxazolo[4, 5-d]pyridazin-4(5H)-one, hot-plate test, writhing test, analgesic effect