- Turkish Journal of Chemistry
- Vol: 35 Issue: 2
- Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3...
Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles
Authors : Asal Fallah Tafti, Tahmineh Akbarzadeh, Parastoo Saniee
Pages : 307-316
Doi:10.3906/sag-1208-4
View : 9 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A series of [(4-nitro-1H-imidazol-1-yl)methyl]-1,2,4- triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their activity against sensitive and resistant H. pylori strains. Study of the structure-activity relationship of these series of compounds indicated that the type of nitroimidazole moiety and the pendent group on the heteroaryl analog dramatically impact the anti-H. pylori activity. In triazole series, compound 5d, containing a 4-methyl phenyl group on the triazole ring, was the most potent compound tested against both metronidazole-sensitive and -resistant strains at a concentration of 8 m g.Keywords : 4-Nitroimidazole, 1, 2, 4-triazoles, 1, 3, 4-thiadiazoles, 1, 3, 4-oxadiazoles, anti-H. pylori activity