- Turkish Journal of Chemistry
- Vol: 35 Issue: 2
- Synthesis, crystal structure, and antioxidant properties of novel 1,2,4-triazol-5-ones containing 3,...
Synthesis, crystal structure, and antioxidant properties of novel 1,2,4-triazol-5-ones containing 3,4-dimethoxyphenyl and 3,4-dihydroxyphenyl moiety
Authors : Yasemin Ünver, Sevgi Meydanal, Kemal Sancak, Dilek Ünlüer
Pages : 265-277
Doi:10.3906/sag-1203-100
View : 15 | Download : 4
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A series of new 4-(3,4-dimethoxyphenethyl)-5-akyl/aryl-2H- 1,2,4-triazol-3(4H)-ones (3a-g) was obtained by the reaction of ethyl 2-(ethoxy)(alkylidene/arylidene)hydrazinecarboxylate (1) and 2-(3,4-dimethoxyphen- yl)ethanamine (2). Compounds 4a-f and 5 were synthesized from the reaction of corresponding compounds 3a-f and 3g with BBr3, respectively. With elemental analysis, IR, 1H-NMR, and ^{13C-NMR spectral data, 14 newly synthesized compounds were characterized. The structure of compound 3a was inferred through IR, ^1H- and ^{13}C-NMR, elemental analysis, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4a, 4c, 4d, 4f, and 5 exhibited the highest degree of antioxidant activity.Keywords : Synthesis, 1, 2, 4-triazole-3-one, antioxidant activity, X-ray