- Turkish Journal of Chemistry
- Vol: 35 Issue: 3
- Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-...
Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones
Authors : Shadia Mahmoud Abdallah, Halima Aly Hefny
Pages : 463-474
Doi:10.3906/vet-1111-22
View : 10 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of a,b-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.Keywords : Microwave, butenamides, pyrrolidines, sulfonamides, biological activity, antiproliferative activity