- Turkish Journal of Chemistry
- Vol: 36 Issue: 1
- One-pot synthesis of fully substituted 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, ...
One-pot synthesis of fully substituted 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, cyclobutanone and N -isocyaniminotriphenylphosphorane
Authors : Mohsen Valizadeh Holagh, Abel Mohammadali Oglu Maharramov
Pages : 179-188
Doi:10.3906/zoo-1202-16
View : 6 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Reactions of N-isocyaniminotriphenylphosphorane with cyclobutanone in the presence of aromatic (or heteroaromatic) carboxylic acids proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1-(5-aryl-1,3,4-oxadiazol-2-yl)- 1-cyclobutanol derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed. The structures of the products were deduced from their IR, 1HNMR, and 13CNMR spectra, and mass spectrometry.Keywords : N-isocyaniminotriphenylphosphorane, intramolecular aza-Wittig reaction, 1, 3, 4-oxadiazole, aromatic carboxylic acid, cyclobutanone