- Turkish Journal of Chemistry
- Vol: 36 Issue: 3
- Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropana...
Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines
Authors : Ali Ramazani, Kourosh Dastanra, Fatemeh Zeinali Nasrabadi
Pages : 467-476
Doi:10.3906/sag-1210-28
View : 14 | Download : 7
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.Keywords : Silica nanoparticles, multicomponent reaction, isocyanide, 2-oxo-2-phenylacetaldehyde, secondary amine, iminium ion