- Turkish Journal of Chemistry
- Vol: 36 Issue: 4
- Determination of lidocaine based on electrocatalysis of a chemically modified electrode
Determination of lidocaine based on electrocatalysis of a chemically modified electrode
Authors : Gamze Tan, Gülçin Bolat, Mehmet Ali Onur, Serdar Abaci
Pages : 593-600
Doi:10.3906/sag-1302-131
View : 14 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.Keywords : Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry