- Turkish Journal of Chemistry
- Vol: 36 Issue: 5
- Chemical and biotransformation of Gelomulide F: a rare diterpene lactone
Chemical and biotransformation of Gelomulide F: a rare diterpene lactone
Authors : Humaira Yasmeen Gondal, And Muhammad Iqbal Choudhary
Pages : 759-763
Doi:10.3906/yer-1208-3
View : 13 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Chemical and biotransformations of a rare diterpene lactone, Gelomulide F (1), from the cytotoxic extract of leaves of Suregada multiflora were studied. Fermentation of compound 1 with Sachromyces cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its treatment with 2N KOH yielded Gelomulide D (2). In addition, a novel compound (4) was obtained by its diastereo and chemoselective reduction with NaBH4. All of these compounds were characterized on the basis of extensive 1H-NMR, 13C-NMR, 2D NMR, and mass spectral analyses.Keywords : Diterpene lactone, Gelomulide, Suregada multiflora, Sachromyces cerevisiae, diastereo and chemoselective reduction