- Turkish Journal of Chemistry
- Vol: 36 Issue: 5
- Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extrac...
Synthesis and characterization of bis(azine) ligands and metal complexes: DNA-interaction and extraction properties for metals and dichromate anions
Authors : Sultan Kulaksizoğlu, Cansu Gökçe, Ramazan Güp
Pages : 717-733
Doi:10.3906/sag-1208-33
View : 15 | Download : 6
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Two new bis(bidentate) azine ligands were prepared by linking (1Z,1'Z)-1,1'-{butane-1,4-diylbis[oxyben-zene-4,1- diyl(1Z)eth-1-yl-1-ylidene]}dihydrazine to salicylaldehyde and pyridine-2-carbaldehyde, 1,4-bis{4-{(1E)-1-((2E)-(2- hydroxybenzene--2-ylmethy-lidene)hydrazonylidene)ethyl}phenoxy}butane (H2L1), and 1,4-bis{4-{(1E)-1-((2E)-(pyridine--2-ylmethylidene) hydrazonylidene)ethyl}phenoxy}butane (L2), respecti- vely. Two kinds of copper(II) and nickel(II) complexes with different ligands were prepared. Reaction of H2L1 with Cu(II) and Ni(II) acetate with 1:1 molar ratio gave double stranded binuclear bis(azine) complexes with stoichiometry [M(L1)]2 containing {MIIN2O2} centers. On the other hand, 1:1 molar ratio reaction of Cu(II) and Ni(II) chloride with L2 yielded mononuclear metal complexes with general stoichiometry [M(L2)Cl2] containing {MIIN2N2} centers. The structures of both bis(azine) ligands and complexes were identified by elemental analysis, infrared spectra, UV--Vis electronic absorption spectra, magnetic susceptibility measurements, and TGA. DNA binding and DNA cleavage activities of the mononuclear complexes of L2, [M(L2)Cl2] were examined by using UV-Vis titration and agarose gel electrophoresis, respectively. The results indicate that mononuclear complexes, especially [Cu(L2)Cl2], bind significantly calf thymus DNA and cleaves pBR322 DNA. Furthermore, the complexing properties of the bis-azine ligands toward selected transition metal cations and dichromate anions were also reported. It was found that bis(azine) ligands have high extraction ability towards dichromate anions.Keywords : Bis(azine), complexes, DNA-interaction, extraction, heavy metals, dichromate anions