- Turkish Journal of Chemistry
- Vol: 36 Issue: 5
- A one-pot efficient four-component reaction for the synthesis of 2-(arylamino)-2-(5-aryl-1-ethenyl-1...
A one-pot efficient four-component reaction for the synthesis of 2-(arylamino)-2-(5-aryl-1-ethenyl-1,3,4-oxadiazol-2-yl)propyl benzoate (or 4-bromobenzoate) derivatives
Authors : Mohsen Valizadeh Holagh, Abel Mohammadalioglu Maharramov
Pages : 671-681
Doi:10.3906/sag-1203-69
View : 11 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Reactions of N-isocyaniminotriphenylphosphorane with 2-oxopropyl benzoate (or 2-oxopropyl 4-bromobenzoate) in the presence of 3-phenyl-2-propynoic acid and primary amines proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed.Keywords : 2-Oxopropyl benzoate, 2-oxopropyl 4-bromobenzoate, 3-phenyl-2-propynoic acid, 1, 3, 4-oxadiazole, N-isocyaniminotriphenylphosphorane