- Turkish Journal of Chemistry
- Vol: 37 Issue: 2
- Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in ph...
Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations
Authors : Gamze Ergin, Sena Çağlar, Armağan Önal, Sıdıka Ertürk Toker
Pages : 171-181
Doi:10.3906/kim-1106-58
View : 8 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as p-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 4--20 m g mL-1, 4--12 m g mL-1, 0.8--2.4 m g mL-1, 4--14 m g mL-1, and 2.5--20 m g mL-1 for atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, respectively. The proposed methods were successfully applied to the pharmaceutical preparations without any interference from excipients.Keywords : HMG-CoA reductase inhibitors, spectrophotometric determination, charge-transfer reaction, TCNQ, pharmaceutical preparations