- Turkish Journal of Chemistry
- Vol: 37 Issue: 4
- Umpolung strategy: advances in catalytic C-C bond formations
Umpolung strategy: advances in catalytic C-C bond formations
Authors : Serkan Eymur, Mehmet Göllü, Cihangir Tanyeli
Pages : 586-609
Doi:10.3906/kim-1303-85
View : 11 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.Keywords : Umpolung, thiamine pyrophosphate (TPP), N-heterocyclic carbene, asymmetric synthesis