- Turkish Journal of Chemistry
- Vol: 37 Issue: 5
- Optimization of synthesizing glucose 1-phosphate by sodium tripolyphosphate as a phosphorus acylatin...
Optimization of synthesizing glucose 1-phosphate by sodium tripolyphosphate as a phosphorus acylating agent using response surface methodology
Authors : Li-e Jin, Fenfen Chang, Xiaojuan Wang, Qing Cao
Pages : 765-774
Doi:10.3906/kim-1210-15
View : 6 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :With glucose as the starting material, sodium tripolyphosphate as the phosphorus acylating agent, and urea as the catalyst, glucose 1-phosphate was synthesized and its properties were analyzed. The synthesis conditions were selected according to the phosphorus content and optimized through the response surface methodology (RSM), based on a 3-level, 3-variable Box--Behnken experimental design. The results showed that the phosphorus content of glucose 1-phosphate was 8.12% using a reaction temperature of 70 °C, a molar ratio of glucose to sodium tripolyphosphate of 1.54:1, and catalyst amount of 3.7 g. It coincided well with the experimental value (8.34%). The structure of the product was confirmed by IR, UV, and 1H NMR spectra; electrical conductivity; TG; and DTA. The proposed method has high phosphorus content and low toxicity.Keywords : Synthesis, sodium tripolyphosphate, glucose 1-phosphate, response surface methodology