- Turkish Journal of Chemistry
- Vol: 38 Issue: 1
- Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles
Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles
Authors : Mehmet Alp, Ali Hakan Göker, Nurten Altanlar
Pages : 152-156
Doi:10.3906/kim-1303-81
View : 10 | Download : 5
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :A new class of 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles (13--22) were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines (1, 4--12) and 1-(4-formylpheny)-1H-benzimidazole (3). The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.Keywords : 1H-Benzimidazole, antimicrobial activities, methicillin resistant Staphylococcus aureus, Candida albicans