- Turkish Journal of Biology
- Vol: 26 Issue: 3
- Hydroxyurea Induces p53 Accumulation and Apoptosis in Human Cervical Carcinoma Cells
Hydroxyurea Induces p53 Accumulation and Apoptosis in Human Cervical Carcinoma Cells
Authors : Hakan Akça
Pages : 145-150
View : 7 | Download : 3
Publication Date : 9999-12-31
Article Type : Makaleler
Abstract :Cervical carcinoma is one type of cancer with a high mortality rate in women. In this research, we investigated the cytotoxic, antiproliferative and apoptosis-inducing effects of hydroxyurea on a human cervical carcinoma cell line, HeLa. We found that hydroxyurea has cytotoxic and antiproliferative effects on HeLa cells in a dose-dependent manner. We also found that hydroxyurea can increase cellular levels of p53 and p21, and induce DNA fragmentation in a dose-dependent manner. We concluded that the observed antiproliferative, cytotoxic and apoptosis inducing activities of hydroxyurea might be mediated by the induction of p53 and its transcriptional target, p21.Keywords : Hydroxyurea, p53, p21, Cervical Carcinoma, DNA fragmentation, Apoptosis