- Selcuk Journal of Agriculture and Food Sciences
- Vol: 23 Issue: 47
- The Antioxidant and Protective Activity of Aromatic Plants Blend Infusion on Streptozotozine (STZ) a...
The Antioxidant and Protective Activity of Aromatic Plants Blend Infusion on Streptozotozine (STZ) and CCl4 Induced Toxicity in Rats
Authors : Khaled F. El-massry, Ahmed H. El-ghorab, Manal M. Ramadan, Ahmed M. Gad
Pages : 77-88
View : 8 | Download : 14
Publication Date : 2009-04-25
Article Type : Research Article
Abstract :The consumption of plant infusions as a healthy tasty drink is a worldwide practice. Various pharmacological activities inherent to aromatic plants have been attributed to their volatiles and phenolic compounds. The present study aimed to prepare a natural healthy drink from blend of five aromatic plants possessing an acceptable flavour and good taste. Plants infusion volatiles were isolated and analyzed using GC and GC/MS, the total phenolic content and in vitro anti-oxidant activity were determined. The effect of aromatic plants infusion on glucose level, kidney function and antioxidant enzyme activities of superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose -6- phosphate dehydrogenase (G-6-PhDH) as well as the level of malondialdehyde (MDA) in different organs of strep-tozotozine (STZ) diabetic rats were determined. Also, plasma urea, creatinine, lipid profile and blood hemoglobin were tested. Activities of transaminases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase and level of total protein and total bilirubin were determined to evaluate the hepatoprotective activity of blend infusion in CCl4- induced toxicity. The results showed that supplementation with aromatic plants blend infusion significantly attenuated toxic effects induced by STZ and CCl4 and protecting liver, kidney, pancreas and maintain the antioxidant status in rats.Keywords : Aromatic plants, Antioxidants, GC-MS, Carbon tetrachloride and Streptozotosine