- Marmara Medical Journal
- Vol: 9 Issue: 2
- Hepatic veno-occlusive disease after bone marrow transplantation
Hepatic veno-occlusive disease after bone marrow transplantation
Authors : C. Canpolat, D. Başdemir
Pages : 0-0
View : 6 | Download : 2
Publication Date : 1996-03-01
Article Type : Research
Abstract :In the first few weeks after bone marrow transplantation, a clinical syndrome characterized by hepatomegaly, jaundice, and fluid retention develops in 10 to 70% of patients. This syndrome is due to damage to endothelial cells, sinusoids, and hepatocytes in zone 3 of thejiver acinus. The proximate cause of the damage is cytoreductive therapy. This syndrome, often called veno-occlusive disease of the liver, can vary in severity from mild reversible disease to fatal disease associated with multiorgan failureKeywords : Hepatic veno-occlusive disease, Bone marrow transplantation, Cytoreductive therapy