- Marmara Medical Journal
- Vol: 9 Issue: 1
- Antinociceptive effects of morphine and physostigmine in different inbred strains of mice
Antinociceptive effects of morphine and physostigmine in different inbred strains of mice
Authors : A. N. Aslan, K. Berkman, B. Çirakoğlu, Ş. Oktay
Pages : 7-10
View : 10 | Download : 4
Publication Date : 1996-01-01
Article Type : Research
Abstract :Antinociceptive effects of morphine and physostigmine, alone or in combination were investigated in mice of BALB/C, C57BL/6 and CB6F1 strains. Morphine and physostigmine increased pain treshold in BALB/C and CB6F1 mice at a dose of 5 mg/kg and 0.1 mg/kg, respectively, whereas C57BL/6 mice were found to be less responsive to both agents. When a nonanalgesic dose of physostigmine (0.05 mg/kg) was combined with a nonanalgesic dose of morphine (2.5 mg/kg), a significant antinociceptive effect was observed in BALB/C and CB6F1 mice, but not in C57BL/6 strain. These results suggest that there is a significant influence of strain on cholinergic and opioid antinociception, and synergistic interaction between cholinergic and opioidergic systems also occur strain-dependently.Keywords : Analgesia, tail-flick, morphine, physostigmine, BALB/C, C57BL76, CB6F1