- Journal of Experimental and Clinical Medicine
- Vol: 40 Issue: 1
- SCUBE-1 as a novel predictor of thromboembolic event
SCUBE-1 as a novel predictor of thromboembolic event
Authors : Hatice Şeyma Akça
Pages : 197-198
View : 52 | Download : 156
Publication Date : 2023-03-18
Article Type : Research Article
Abstract :SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.Keywords : SCUBE-1, thromboembolic events, myocardial infarction