- Journal of Scientific Reports-A
- Issue: 051
- DETERMINATION of SOME ANTIOXIDANT ACTIVITIES and OXIDATIVE STRESS LEVES in PATIENTS with LIP and ORA...
DETERMINATION of SOME ANTIOXIDANT ACTIVITIES and OXIDATIVE STRESS LEVES in PATIENTS with LIP and ORAL CAVITY CANCER
Authors : Ali Hussein Mer, Halil Özkol, Halit Demir, Şeyda Belli, Canan Demir, Ali Aslan
Pages : 49-56
View : 9 | Download : 4
Publication Date : 2022-12-31
Article Type : Other
Abstract :Squamous cell carcinomas constitute the majority of oral cavity tumors. Poor oral hygiene, smoking, chronic irritation and alcohol consumption are counted as etiological factors. In study, it was aimed to determine oxidative stress levels and some antioxidant activities such as superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) in cancer of the lip and oral cavity. Malondialdehyde (MDA) levels, SOD, GSH and CAT activities were measured using the spectrophotometric method. The results showed that SOD, CAT and GSH levels decreased significantly in the patient group (p<0.05), while MDA levels increased significantly (p<0.05). Lack of antioxidants can increase the development of oral and lip cancers.Keywords : Lip and oral cavity cancers, SOD, GSH, CAT, MDA