- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 10 Issue: 3
- Novel Perylene-Based Antimicrobial PDI Chromophores
Novel Perylene-Based Antimicrobial PDI Chromophores
Authors : Cansu Yilmaz, Pınar Güner, Tülin Aşkun, Funda Yükrük
Pages : 633-640
Doi:10.18596/jotcsa.1292068
View : 56 | Download : 56
Publication Date : 2023-08-30
Article Type : Research Article
Abstract :The main goal of the study was to monitor the Antimicrobial activity of two novel perylene diimides which were synthesized and characterized. Antimicrobial activity was investigated against Four Mycobacterium tuberculosis strains (MT) (Mt-H37Rv, Mt-H37Ra and two clinical isolates) and two Staphylococcus aureus strains [Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (SA)]. Minimum inhibitory concentrations (MICs) and minimum bactericidal activity (MBCs) were determined. Both compounds exhibited bactericidal effects and MICs were found to be changing in the range of 48-96 µg/mL for four MT-strains. Compounds were also effective on Staphylococcus strains at MIC = 96 µg/mL.Keywords : Perylene diimide, Antimicrobial activity, Mycobacterium tuberculosis, Methicillin resistant, Staphylococcus aureus, MIC, MBC