- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 10 Issue: 2
- Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazol...
Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes
Authors : Mehtap Tuğrak Sakarya, Halise Inci Gül, Cem Yamali, Parham Taslimi, Tugba Taskin Tok
Pages : 385-424
Doi:10.18596/jotcsa.1111172
View : 93 | Download : 124
Publication Date : 2023-05-31
Article Type : Research Article
Abstract :Alzheimer\'s disease (AD) and diabetes mellitus (DM) are related to abnormal changes in enzyme activity. While acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the primary targets in the treatment of Alzheimer\'s disease (AD), α-glucosidase (α-Gly) and α-amylase (α-Amy) enzymes are known for diabetes mellitus (DM). Here, benzenesulfonamide-based thiourea and thiazolidinone derivatives such as AChE, BChE, α-Gly, and α-Amy inhibitors were reported. The results revealed that compounds 1d and 2c showed promising AChE and BChE inhibition effects. Compound 2a was the most potent inhibitor against α-glycosidase and α-amylase, respectively. Molecular docking studies indicated that the lead compounds\' binding energy values and molecular interactions were better than that of tacrine and acarbose. The most bioactive compounds may be considered potent leads for further studies.Keywords : Thiazolidinone, Benzamide, Alzheimer’s disease, Diabetes Mellitus, Molecular Docking, Synthesis