- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 8 Issue: 4
- Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper
Authors : Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Jafri Malin Abdullah, Mohd. Zaheen Hassan, Mohamad Nurul Azmi Mohamad Taib
Pages : 995-1002
Doi:10.18596/jotcsa.904529
View : 10 | Download : 8
Publication Date : 2021-11-30
Article Type : Research
Abstract :Bamboo shoots of Dendrocalamus asper is very important for human health because of its high content of dietary fiber, low sugar, negligible amount of fat, rich in vitamins and minerals. In search of new potential antimalarial agents, the chemical constituents of bamboo shoots were evaluated againts the P. falciparum strain 3D7. One new metabolite, (11E,13E,17E,19E)-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate (1) along with the four known compounds; β-sitosterol (2), methyl-4-hydroxybenzoate (3), 1-methoxy-4-(methoxymethyl)benzene (4) and 4-hydroxybenzaldehyde (5) were isolated from the crude extract using chromatographic methods: MPLC, UPLC/MS, analytical and preparative HPLC. Among these, compounds 1, 3 and 4 showed promising antimalarial activity with IC50 between 0.8-2.2 μg/mL. The molecular docking between the most potent compound 3 and dihydrofolate reductase-thymidylate synthase (DHFR-TS) was done to understand and exploring ligand-receptor interactions and hypothesize the compound's refinementsKeywords : Dendrocalamus asper, antimalarial, P. Falciparum, Molecular docking, dihydrofolate reductase-thymidylate synthase (DHFR-TS)