- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 4 Issue: 3
- The Spectroscopic and Thermal Properties, Antimicrobial Activities and DNA Interactions of 4-(Fluoro...
The Spectroscopic and Thermal Properties, Antimicrobial Activities and DNA Interactions of 4-(Fluorobenzyl)Spiro(N/O) Cyclotriphosphazenium Salts
Authors : Gamze Elmas, Aytuğ Okumuş, Zeynel Kılıç, Süheyla Pınar Çelik, Leyla Açık
Pages : 993-1016
Doi:10.18596/jotcsa.316902
View : 19 | Download : 7
Publication Date : 2017-06-13
Article Type : Research
Abstract :The protic ionic liquids (PILs) ( 3a-3d ) were synthesized from the reactions of tetraamino-4-(fluorobenzyl)spiro(N/O)cyclotriphosphazenes ( 2a-2d ) with the gentisic acid in THF. The structures of the PILs were verified by elemental analyses, Fourier transform infrared (FTIR), 1 H, 13 C { 1 H} and 31 P { 1 H} NMR techniques. The thermal properties of the PILs were evaluated using TG/DTG/DTA instrument. On the other hand, the antimicrobial activities of the PILs were examined against some bacteria and fungi, and the obtained results were compared with the evaluations of the corresponding fully substituted cyclotriphosphazene bases. The interactions between the PILs and supercoiled PBR322 DNA were also scrutinized, and it was determined that they exhibited significant conformational changes.Keywords : PILs, Thermal analysis, Spectroscopy, Antimicrobial activity, DNA binding