- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 3 Issue: 3 Special Issue
- SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITIES OF NOVEL 1-(MORPHOLINE-4-YL-METHYL)-3-ALKYL(A...
SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITIES OF NOVEL 1-(MORPHOLINE-4-YL-METHYL)-3-ALKYL(ARYL)-4-[4-(DIMETHYLAMINO)-BENZYLIDENAMINO]-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-5-ONES
Authors : Özlem Gürsoy Kol, Haydar Yüksek, Sevda Manap, Feyzi Sinan Tokalı
Pages : 105-118
Doi:10.18596/jotcsa.23635
View : 17 | Download : 4
Publication Date : 2017-01-08
Article Type : Other
Abstract :In this paper, eight novel 1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-[4-(dimethylamino)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones ( 2 ) were obtained by the reactions of 3-alkyl(aryl)-4-[4-(dimethylamino)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones ( 1 ) with formaldehyde and morpholine. The novel synthesized compounds were identified by IR, 1 H NMR and 13 C NMR spectral data. Besides, the newly synthesized compounds were analysed for their in vitro potential antioxidant capacities in three different assays. All of the compounds demonstrated significant activity for metal chelating effect.Keywords : 4, 5-Dihydro-1H-1, 2, 4-triazol-5-one, Syntheses, Mannich base, Antioxidant capacity.